Most Recent CIFASD Publications
((((((((((((((((((((((((AA014786[Grant Number]) OR (AA014790[Grant Number])) OR (AA014809[Grant Number])) OR (AA014811[Grant Number])) OR (AA014812[Grant Number])) OR (AA014815[Grant Number])) OR (AA…
- Consortium Profile: The Methylation, Imaging and NeuroDevelopment (MIND) ConsortiumEpigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual differences in the brain itself. An increasingly popular approach to address this is by combining epigenetic and […]Isabel K Schuurmans
- Teachers' needs for an FASD-informed resource: a qualitative interview needs assessment based on the ADAPT-ITT frameworkCONCLUSIONS: Teachers need an evidence-based FASD-informed intervention that is easy to use, concise, and responsive to varying needs and levels of experience. Results will inform the adaptation process of the FMF Program.C Kautz-Turnbull
- Child Ability and Parental Attributions: Development and Validation of the Reasons for Children's Behavior ScaleParent attributions for children's behavior affect parenting practices and emotional reactions. The current study aimed to create a new measure of parental attributions, called the Reasons for Children's Behavior (RCB), to capture how parents take developmental ability into account when making attributions for specific behaviors. A 224-item survey was completed by 836 participants, including original […]Carson Kautz-Turnbull
- Adaptive, Externalizing, and Internalizing Behavior of Children with Prenatal Alcohol Exposure: A Comparison of Three Parent-Report QuestionnairesThis study compared the Behavior Assessment System for Children-Third Edition (BASC-3) to the Child Behavior Checklist (CBCL) and the Vineland Adaptive Behavior Scales-Third Edition (VABS-3) in children with and without histories of prenatal alcohol exposure. Data were collected from Collaborative Initiative on Fetal Alcohol Spectrum Disorders Phase 4 sites. Caregivers rated their child's behavior using […]Chloe M Sobolewski
- Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disordersA hallmark of fetal alcohol spectrum disorders (FASD) is neurobehavioral deficits that still do not have effective treatment. Here, we present that reduction of Apolipoprotein E (APOE) is critically involved in neurobehavioral deficits in FASD. We show that prenatal alcohol exposure (PAE) changes chromatin accessibility of Apoe locus, and causes reduction of APOE levels in […]Hye M Hwang
- Lower resting state functional connectivity partially mediates adverse effects of prenatal alcohol exposure on arithmetic performance in childrenCONCLUSION: This study demonstrates PAE-related functional connectivity impairments in functional networks involved in number processing. The weaker connectivity between the R posterior superior parietal lobule and the L inferior frontal gyrus suggests that impaired verbal processing and visuospatial working memory may play a role in number processing deficits, while weaker connectivity between the R intraparietal […]Jia Fan
- Language outcomes of preschool children who are HIV-exposed uninfected: An analysis of a South African cohortINTRODUCTION: There are approximately 16 million children who are HIV-exposed and uninfected (CHEU) worldwide. Studies suggest that CHEU are at risk for developmental impairment in infancy, particularly in language domains. However, there is limited research examining neurocognitive function in CHEU older than 2 years, including important pre-school years. This study aimed to investigate associations between […]Freddy Green
- Association of in utero HIV exposure with child brain structure and language development: a South African birth cohort studyCONCLUSIONS: In this cohort study, exposure to HIV during pregnancy was associated with altered cortical structure in early life. Our findings indicate that differences in cortical thickness development in the prefrontal region in children who are HEU may be a pathway leading to language impairment. Longitudinal studies are needed to determine the lasting impact.Catherine J Wedderburn
- Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell deathThe mechanistic target of rapamycin (mTOR) coordinates metabolism and cell growth with environmental inputs. mTOR forms two functional complexes: mTORC1 and mTORC2. Proper development requires both complexes but mTORC1 has unique roles in numerous cellular processes, including cell growth, survival and autophagy. Here, we investigate the function of mTORC1 in craniofacial development. We created a […]Scott K Tucker
- Validation of the ND-PAE Diagnosis in Children with Heavy Prenatal Alcohol ExposureThis study evaluated criteria for Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE). Kable et al. (2022) assessed the validity of this diagnosis in a sample with low exposure to alcohol. The current study expanded this assessment to a sample with a wider age range and heavier alcohol exposure. Data were collected from participants (5-17y) […]Christina R Veziris