Pregnancy and infancy characteristics were used to best predict which children would later be diagnosed with a fetal alcohol spectrum disorder (FASD).
By identifying predictive models that accurately classify children as at-risk of FASD, allow for earlier screening and intervention. Early identification and treatment for children with FASD optimizes outcomes.
See: https://onlinelibrary.wiley.com/doi/full/10.1111/acer.15233
Available data dictionaries:
Phase 1: Phase 1 Data Dictionary (2003-2007)
Phase 2: Phase 2 Data Dictionary (2007-2012)
Phase 3: Phase 3 Data Dictionary (2012-2017)
Available data from Phase I were collected across five sites:
(1) Center for Behavioral Teratology, San Diego State University, San Diego, CA;
(2) Seven Northern Plains communities, including six Indian reservations;
(3) Institute of Psychiatry, Moscow, Russia;
(4) Moscow Region Institute of Obstetrics and Gynecology, Moscow, Russia, and
(5) Omni-Net sites at the Rivne Diagnostic Center, and the Kherson Children’s Hospital, Rivne and Kherson, Ukraine.
Subject recruitment varied between the sites, and subject population was racially and ethnically diverse.
Data for Neurobehavior, Dysmorphology Demographics, 3D Facial Imaging were collected from sites 1-3 for children between the ages of 5 -18 years, although the majority were 7-18 years old.
Data on current and recent maternal alcohol consumption, demographics and pregnancy history in a prospective study of prenatal alcohol exposure were collected from mothers and their babies from sites 4-5. Dysmorphology data was collected for all participants.
Data collected from infants in a prospective study.
Phase II
Phase III
Phase 1 – data include measures from the Leiter, NES3, DKEFS, CANTAB, CBC and other scales
Phase 2 – data include measures from the Leiter, DKEFS, CANTAB, BRIEF, ASEBA, Vineland, C-DISC, and other scales
Phase 3 – data include measures from the DAS-II, NEPSY-II, CANTAB, BRIEF, ASEBA, Vineland, C-DISC and other scales
Phase I
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Phase II
Phase III
MRI data were collected in Phase 2 and 3
PLINK files are provided for GWAS data
VCF files are provided for whole exome sequencing data
3D Facial Imaging data were collected in all phases of CIFASD
Phase I
Phase II
Phase III
Dysmorphology data were collected from all phases and some individuals have been examined longitudinally. These data include information on height, weight, head circumference and other physical measures, as well as philtrum score, thin vermillion border score, and palpebral figure length.
Data include information (when known) on the birth (e.g., weight, length maternal substance use), and alcohol exposure information.
Available data from Phase III were collected across five sites:
(1) San Diego State University,
(2) Emory University,
(3) University of California, Los Angeles and Children’s Hospital Los Angeles, CA,
(4) University of Minnesota; and
(5) Omni-Net locations in Ukraine: the Rivne Diagnostic Center and the Khmelnytsky Perinatal Center in Rivne and Khmelnytsky, Ukraine.
Subject recruitment varied between the sites, and subject population was racially and ethnically diverse.
Data for Neurobehavior, Dysmorphology, Demographics, 3D Facial Imaging, Genetics, and Brain Volume were collected from sites 1-4 for children ages 5-7 and 10-16 years under two age-based protocols. Data from maternal blood samples were collected from pregnant women and fetal data were collected via ultrasound from mothers and babies at site 5. Live born infants were given a dysmorphology exam, facial imaging, and neurobehavioral testing. Collection of blood, urine, and cheek cell samples were also included.
Available data from Phase II were collected across six sites:
(1) Center for Behavioral Teratology, San Diego State University, San Diego, CA;
(2) Emory University, Atlanta, GA;
(3) the University of California, Los Angeles, Los Angeles, CA;
(4) University of New Mexico, Albuquerque, NM;
(5) Seven Northern Plains communities, including six Indian reservations; and
(6) Omni-Net locations in Ukraine: the Rivne Diagnostic Center and the Khmelnytsky Perinatal Center in Rivne and Khmelnytsky, Ukraine.
Subject recruitment varied between the sites, and subject population was racially and ethnically diverse.
Data for Neurobehavior, Dysmorphology, Demographics and Brain Volume were collected from sites 1-5 for children between the ages of 8-16 years. 3D Facial Imaging and Genetic data are also available for children from sites 1-3. Data from a longitudinal study were collected from site 6 for 350 moderately to heavily alcohol-exposed pregnant women and approximately 350 low or unexposed women.
Pregnancies were followed with serial ultrasounds and maternal blood samples were collected and analyzed for various nutrients and markers of oxidative stress and inflammation. Live born infants were given a dysmorphology exam, facial imaging, and neurobehavioral testing.